Sooooo .. what's the answer of the "caliber+weight" fanclub to the thousands of 300, 400, 500+ pound alligators being shot and instantly killed every year with a single 22 caliber 40 grain bullet travelling at pistol speeds.
Despite all the caliber/weight/pistol discussion, in all seriousness - if you have a dedicated home defense gun it should be shoulder fired, I really hope I'm not alone here with that opinion.My nightstand gun is a G21 with Arrendondo +4's, loaded with 230gr Gold Dots. Nothing says GTFO like 18 rounds of .45!