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The Water Cooler
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CDC admits death toll is inflated! Of 161,392 deaths ONLY 6% / 9,683 ARE DIRECTLY CAUSED BY COVID.
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<blockquote data-quote="_CY_" data-source="post: 3428637" data-attributes="member: 7629"><p><a href="https://twitter.com/JamesTodaroMD?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1292873243104247809%7Ctwgr%5Eshare_3&ref_url=https%3A%2F%2Fwww.redstate.com%2Fmichael_thau%2F2020%2F09%2F24%2Fwatch-trumps-new-covid-explain-covid-science-to-room-of-people-who-majored-in-journalism-at-breifing%2F" target="_blank"><img src="https://pbs.twimg.com/profile_images/1042451482803675136/1AILlGY-_bigger.jpg" alt="" class="fr-fic fr-dii fr-draggable " style="" /></a></p><p><a href="https://twitter.com/JamesTodaroMD?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1292873243104247809%7Ctwgr%5Eshare_3&ref_url=https%3A%2F%2Fwww.redstate.com%2Fmichael_thau%2F2020%2F09%2F24%2Fwatch-trumps-new-covid-explain-covid-science-to-room-of-people-who-majored-in-journalism-at-breifing%2F" target="_blank">James Todaro, MD</a></p><p><a href="https://twitter.com/JamesTodaroMD?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1292873243104247809%7Ctwgr%5Eshare_3&ref_url=https%3A%2F%2Fwww.redstate.com%2Fmichael_thau%2F2020%2F09%2F24%2Fwatch-trumps-new-covid-explain-covid-science-to-room-of-people-who-majored-in-journalism-at-breifing%2F" target="_blank">@JamesTodaroMD</a></p><p>7/ This finding was confirmed in yet another study published in Cell in June 2020 showing that 40-60% of unexposed individuals had T cell recognition of SARS-CoV-2. The authors hypothesized that crossover immunity came from “common cold” coronaviruses.</p><p><a href="https://t.co/v2boTH9xVa?amp=1" target="_blank"></a></p><p><a href="https://t.co/v2boTH9xVa?amp=1" target="_blank"><img src="https://pbs.twimg.com/card_img/1306257520776839173/yIvg24lY?format=jpg&name=240x240" alt="" class="fr-fic fr-dii fr-draggable " style="" /></a></p><p><a href="https://t.co/v2boTH9xVa?amp=1" target="_blank">Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed...</a></p><p><a href="https://t.co/v2boTH9xVa?amp=1" target="_blank">Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and…</a></p><p><a href="https://t.co/v2boTH9xVa?amp=1" target="_blank">sciencedirect.com</a></p><p><a href="https://twitter.com/JamesTodaroMD/status/1292873243104247809?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1292873243104247809%7Ctwgr%5Eshare_3&ref_url=https%3A%2F%2Fwww.redstate.com%2Fmichael_thau%2F2020%2F09%2F24%2Fwatch-trumps-new-covid-explain-covid-science-to-room-of-people-who-majored-in-journalism-at-breifing%2F" target="_blank">12:19 PM · Aug 10, 2020</a></p><p></p><p><span style="font-size: 22px"><strong>Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals</strong></span></p><p><span style="font-size: 22px"><strong><a href="https://www.sciencedirect.com/science/article/pii/S0092867420306103?via%3Dihub" target="_blank">https://www.sciencedirect.com/science/article/pii/S0092867420306103?via=ihub</a></strong></span></p><p><span style="font-size: 22px"></span></p><p><span style="font-size: 22px"><strong>Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic control measures. Using HLA class I and II predicted peptide “megapools,” circulating SARS-CoV-2-specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively. CD4+ T cell responses to spike, the main target of most vaccine efforts, were robust and correlated with the magnitude of the anti-SARS-CoV-2 IgG and IgA titers. The M, spike, and N proteins each accounted for 11%–27% of the total CD4+ response, with additional responses commonly targeting nsp3, nsp4, ORF3a, and ORF8, among others. For CD8+ T cells, spike and M were recognized, with at least eight SARS-CoV-2 ORFs targeted. Importantly, we detected SARS-CoV-2-reactive CD4+ T cells in ∼40%–60% of unexposed individuals, suggesting cross-reactive T cell recognition between circulating “common cold” coronaviruses and SARS-CoV-2.</strong></span></p><p><span style="font-size: 22px"></span></p><p><span style="font-size: 22px"><strong><span style="font-size: 18px"><strong>Graphical Abstract</strong></span></strong></span></p><p><span style="font-size: 22px"></span></p><p><span style="font-size: 22px"><strong><img src="https://ars.els-cdn.com/content/image/1-s2.0-S0092867420306103-fx1.jpg" alt="" class="fr-fic fr-dii fr-draggable " style="" /></strong></span></p><ol> <li data-xf-list-type="ol"><a href="https://ars.els-cdn.com/content/image/1-s2.0-S0092867420306103-fx1_lrg.jpg" target="_blank">Download : Download high-res image (143KB)</a></li> <li data-xf-list-type="ol"><a href="https://ars.els-cdn.com/content/image/1-s2.0-S0092867420306103-fx1.jpg" target="_blank">Download : Download full-size image</a></li> </ol><p><img src="https://ars.els-cdn.com/content/image/1-s2.0-S0092867420306103-fx1_lrg.jpg" alt="" class="fr-fic fr-dii fr-draggable " style="" /></p></blockquote><p></p>
[QUOTE="_CY_, post: 3428637, member: 7629"] [URL='https://twitter.com/JamesTodaroMD?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1292873243104247809%7Ctwgr%5Eshare_3&ref_url=https%3A%2F%2Fwww.redstate.com%2Fmichael_thau%2F2020%2F09%2F24%2Fwatch-trumps-new-covid-explain-covid-science-to-room-of-people-who-majored-in-journalism-at-breifing%2F'][IMG]https://pbs.twimg.com/profile_images/1042451482803675136/1AILlGY-_bigger.jpg[/IMG] James Todaro, MD @JamesTodaroMD[/URL] 7/ This finding was confirmed in yet another study published in Cell in June 2020 showing that 40-60% of unexposed individuals had T cell recognition of SARS-CoV-2. The authors hypothesized that crossover immunity came from “common cold” coronaviruses. [URL='https://t.co/v2boTH9xVa?amp=1'] [IMG]https://pbs.twimg.com/card_img/1306257520776839173/yIvg24lY?format=jpg&name=240x240[/IMG] Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed... Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and… sciencedirect.com[/URL] [URL='https://twitter.com/JamesTodaroMD/status/1292873243104247809?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1292873243104247809%7Ctwgr%5Eshare_3&ref_url=https%3A%2F%2Fwww.redstate.com%2Fmichael_thau%2F2020%2F09%2F24%2Fwatch-trumps-new-covid-explain-covid-science-to-room-of-people-who-majored-in-journalism-at-breifing%2F']12:19 PM · Aug 10, 2020[/URL] [SIZE=6][B]Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals[/B] [B][URL='https://www.sciencedirect.com/science/article/pii/S0092867420306103?via%3Dihub']https://www.sciencedirect.com/science/article/pii/S0092867420306103?via=ihub[/URL][/B] [B]Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic control measures. Using HLA class I and II predicted peptide “megapools,” circulating SARS-CoV-2-specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively. CD4+ T cell responses to spike, the main target of most vaccine efforts, were robust and correlated with the magnitude of the anti-SARS-CoV-2 IgG and IgA titers. The M, spike, and N proteins each accounted for 11%–27% of the total CD4+ response, with additional responses commonly targeting nsp3, nsp4, ORF3a, and ORF8, among others. For CD8+ T cells, spike and M were recognized, with at least eight SARS-CoV-2 ORFs targeted. Importantly, we detected SARS-CoV-2-reactive CD4+ T cells in ∼40%–60% of unexposed individuals, suggesting cross-reactive T cell recognition between circulating “common cold” coronaviruses and SARS-CoV-2.[/B] [B][SIZE=5][B]Graphical Abstract[/B][/SIZE][/B][/SIZE] [SIZE=6] [B][IMG]https://ars.els-cdn.com/content/image/1-s2.0-S0092867420306103-fx1.jpg[/IMG][/B][/SIZE] [LIST=1] [*][URL='https://ars.els-cdn.com/content/image/1-s2.0-S0092867420306103-fx1_lrg.jpg']Download : Download high-res image (143KB)[/URL] [*][URL='https://ars.els-cdn.com/content/image/1-s2.0-S0092867420306103-fx1.jpg']Download : Download full-size image[/URL] [/LIST] [IMG]https://ars.els-cdn.com/content/image/1-s2.0-S0092867420306103-fx1_lrg.jpg[/IMG] [/QUOTE]
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CDC admits death toll is inflated! Of 161,392 deaths ONLY 6% / 9,683 ARE DIRECTLY CAUSED BY COVID.
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