I use a 125gr jhp from rmr, or a cast Lee 125gr LRNFP I cast from wheel weights. I use 2400 or H110 and a lot of it. These are from a Speer #10 manual..17.5 starting and 19.5 MAX with a mag primer for 2400. I use 17gr with std. primer and get great accuracy. Loads for H110 are 19.6 starting and 21.6 MAX. I use 20gr with a mag primer and get great accuracy with that also. I shoot them in a SP101, GP100, Security Six 2"bbl, & a Marlin lever action. I have so many powders and different bullet combinations since I've started casting my own I have a lot of testing/shooting to do before I land on a favorite.
I shoot a 158gn GDHP atop 13.0 grn of Blue Dot with a standard primer. It's hotter than the new Speer book #14 manual, but it was printed in the #10 manual. Shows 1328fps. Hits like a freight train.