If she wants a 22 that badly, I'd steer her to a 25 auto at the minimum. It's only 0.03 inches larger in diameter. The 25 auto was designed specifically to be used in 22 rimfire size weapons with a much higher ammo reliability (typical centerfire pistol ammo construction vs. the rebated heel bullet design of the 22 rimfire). I don't know if John Moses Browning specifically was involved in designing it, but he wasn't far away from its' development as well as the 32 auto development. Yes, I know, 25 (and 32) auto ammo is expensive and harder to find compared to 22LR, but it's more reliable. The path for oil (from handling the ammo or an over-oiled pistol) to get to the priming compound is much further for the centerfire 25 (or 32) auto compared to the 22 rimfire with its' rebated heel bullet design.
The 22 magnum is another round to consider; it also uses the more modern design of the bullet seated mostly into the case even if it is a rimfire also.
IMHO, but if someone really wants to carry a 22LR for semi-serious defense, it should be a double action revolver. That way when (NOT if) a round fails to fire they can just pull the trigger again to fire. Really, if a 22LR is the only thing they will carry, are you delusional enough to think they'll actually practice any kind of failure drills for a semi-auto pistol????????????
The 22 magnum is another round to consider; it also uses the more modern design of the bullet seated mostly into the case even if it is a rimfire also.
IMHO, but if someone really wants to carry a 22LR for semi-serious defense, it should be a double action revolver. That way when (NOT if) a round fails to fire they can just pull the trigger again to fire. Really, if a 22LR is the only thing they will carry, are you delusional enough to think they'll actually practice any kind of failure drills for a semi-auto pistol????????????