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<blockquote data-quote="-Pjackso" data-source="post: 4287821" data-attributes="member: 8119">Insulin is produced by Pancreatic Beta cells.Beta cells grow at only 1 time in your life: Birth to about 10 years old.&nbsp; After that, that&#039;s all the beta cells you will ever have for the rest of your life.Given time (decades) beta cells die off, and your beta cell mass is less.This is why a majority of T2D is in older people (after beta cell mass has naturally died off).&nbsp; Typically, T2D blood glucose problems (hyperglycemia) starts as you near 30% of your original beta cell mass.T2D patients still produce insulin, but at much lower production levels.&nbsp; Most of the &quot;loose weight, diet, and exercise&quot; tactics are just a means to reduce your body&#039;s need for insulin.&quot;Lifestyle, diet, and exercise&quot; definitely helps, but it&#039;s not a &#039;cure&#039;.&nbsp; Rather - it&#039;s adjusting lifestyle for living within your reduced insulin production means.HIGH blood glucose is toxic to beta cells, which can accelerate beta cell death (of what&#039;s left).If not managed, T2D can lead to insulin-dependent diabetes, sometimes called Type 1.5 diabetes.All this info, just to say - &#039;lifestyle, diet, and exercise &#039; does not address the root cause.&nbsp; But rather, living within your (insulin)&nbsp; means.Note: Healthy people get T2D first, then the metabolic problems follows months/years later.&nbsp; It&#039;s not entirely their fault.I&#039;ve read hundreds of PubMed articles regarding Diabetes, but I&#039;m still no expert.&nbsp; I&#039;d be interested in any &quot;root cause&quot; discussion of what causes(?) T2D.</blockquote>

[QUOTE="-Pjackso, post: 4287821, member: 8119"] Insulin is produced by Pancreatic Beta cells. Beta cells grow at only 1 time in your life: Birth to about 10 years old. After that, that's all the beta cells you will ever have for the rest of your life. Given time (decades) beta cells die off, and your beta cell mass is less. This is why a majority of T2D is in older people (after beta cell mass has naturally died off). Typically, T2D blood glucose problems (hyperglycemia) starts as you near 30% of your original beta cell mass. T2D patients still produce insulin, but at much lower production levels. Most of the "loose weight, diet, and exercise" tactics are just a means to reduce your body's need for insulin. "Lifestyle, diet, and exercise" definitely helps, but it's not a 'cure'. Rather - it's adjusting lifestyle for living within your reduced insulin production means. HIGH blood glucose is toxic to beta cells, which can accelerate beta cell death (of what's left). If not managed, T2D can lead to insulin-dependent diabetes, sometimes called Type 1.5 diabetes. All this info, just to say - 'lifestyle, diet, and exercise ' does not address the root cause. But rather, living within your (insulin) means. Note: Healthy people get T2D first, then the metabolic problems follows months/years later. It's not entirely their fault. I've read hundreds of PubMed articles regarding Diabetes, but I'm still no expert. I'd be interested in any "root cause" discussion of what causes(?) T2D. [/QUOTE]

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