I have several 'favorites'. But if I had to just choose one it would be my S&W Model 681 L-frame. I am big enough to conceal an N-frame, so I sometimes carry a 625 in 45 ACP. I rarely carry my 627 because it is an eight-shooter and the only speed loaders for it are the Bianchi speed-strips. I'd prefer the 627 except for the issue of the speedloaders.
PS There are also the Tuff products speed strips.
Sarsilmaz Hancer 2000. Heavy but it reminds you it's there. Only leather I could find for it is the Don Hume PCH for the Taurus PT111. Boy does that little wonder shoot. Excellent CZ pattern gun.