If you aren't going to save pelts the 110gr. bullets are devastating, just don't push them to fast go for the most accurate you can get. I have shot several deer with these bullets, although the are thin jackets, they worked most of the deer I shot with them were head shots and it was ugly. I have shot several though the lungs and they dropped pretty fast, but if you shoot them in the shoulder or quartering these will not do the job. now we use 130gr bullets and 3031 powder in the 30-06 and it works for everything. I think of varminting as high volumes of shooting, this being said you are going to burn alot of powder.