I carry a S&W M&P Compact and I have found that I like carrying it to the left of my package. Meaning the gun barrel is just to the left of the package and the handle will then be centered. Since it is on the left, the "easy-access" slot in your underwear is sorta on the right and if you can get used to working it out that way, it's not that bad
However, when you receive the Holster, they send decent instructions on how to maneuver in different situations.
That makes sense. Kinda pull the holster a little off center a bit, might also make it easier to set down and not smash any important stuff.