I've never been enthused by Maher's monologues because it is still an exercise in getting laughs. (Oh and for the record, I think many in his "studio audience" are there each and every day. Laughs sometime sound like laughs from a week or so before.) That said, he touches on some good points on sexuality in this monologue. He kind of takes the gay and trans folks to school, although they probably won't do their homework.
