You must tailor the load for that specific barrel, receiver and stock combination, then be consistent in putting it all together. As Dennis said, that can vary with temperature and altitude, depending on what powder you use. Sometimes, a tenth of grain can make a big difference. I have some rifles that will group about an inch, then shrink to half that with a tenth of a grain adjustment ... be that up or down. It's not tied directly to velocity or pressure. Just like people, every rifle is different.