Colchicine both helps prevent the attacks and when one does happen, it helps alleviate it. I normally take one pill in the morning and one at night, but I take two (on advice of my doctor) when an attack does occur, and thankfully, it's starting to kick in. The crappy thing about Colchicine is it can cause severe diarrhea. Oh well, I'd rather hit the pot a few times than be all crippled up. 3 of the things would sideline an elephant with the Hershey squirts I'd bet.