I have been running my 10mm at max load with PC 200 grain bullets and have had zero issues. I had to read a lot of data on the 10mm forums before I gave it a try with longshot powder but it works well. I have not looked into other calibers or powders as of yet but it may be something to study when running PC bullets. Again I worked up to the max load to make sure there were no issues and did it again when I converted the 45acp to 10mm. (both Glocks with factory 10mm barrels)