So geography is the determining factor in whether a populace has the right for self-determination. Thanks for the enlightenment. So what the Founding Fathers meant to say in the Declaration of Independence was...
"But when a long train of abuses and usurpations, pursuing invariably the same Object evinces a design to reduce them under absolute Despotism, it is their right, it is their duty, to throw off such Government, and to provide new Guards for their future security*...."
*but only when you are separated by an ocean and have other world or regional powers supporting your cause
This does not mean run away and form another country. Let me give you another quote.
“These are the times that try men's souls. The summer soldier and the sunshine patriot will, in the crisis, shrink from the service of his country; but he that stands it NOW, deserves the love and thanks of man and woman.”
― Thomas Paine, The American Crisis