+P+ is 9mm's attempt to act like a .45.
My personal opinion on it, is +P+ 9mm is probably best during cold months to punch through more clothing, but in summer there is too much penetration. Whereas +P compensates for the HP and expansion and would be close to penetration (and overpenetration) of ball 9mm. In .45 if I am using HP/SD I really want +p to help push the penetration up just a little more because it's bigger and slower to begin with. If I was going to be carrying standard power .45 I would just carry ball.