I got lucky and got one with a running shot, but don’t recommend it.
The buck went down after being shot. As I walked up to it, the deer jumped up and stumbled across an open wheat field.
Sat down, got a good sight pic and pulled the trigger.
He went down with minimal meat loss.
Depends on angle, distance, rest, movement, temp, humidity, phase of moon, time of the month, ....
When things are perfect, neck shot. Not ideal, but good shot possible; heart lung.
I shot a doe, quartering away, with a 7mag, 140 gr HP. Hit left side, last rib, through heart, exited between right shoulder and base of neck. She ran 100 yards like it was a clean miss.
When I opened her up, chest was full of goo. Everything obliterated.
I have always aimed just behind shoulder for heart and lung shots I have only had one run more than 10 yards and it was because I rushed the shot and hit further back on the lungs.