I was worried about this very thing, and I chronographed a few rounds of a batch and then tumbled some more of it and chronographed it. I couldn't see any difference in velocity between the tumbled batch and the non tumbled batch. This was with ball powder, and I don't know what the results would be with flake or extruded powders, but I suspect they wouldn't change either. Real long duration might abrade the powder to the extent that it burned at a faster rate, then pressures would probably go up substantially. The longest I have tumbled any was about 12 hours and that was by accident. Still no problem with the rounds. Thats just my experience.. Blitzfike