Shot placement matters over anything else. You can't miss with a hand cannon well enough to stop a determined threat.
Don't forget; Ronald Reagan was damn near killed by a .22lr. He was a big, muscular dude back in the day and Hinckley's bullet entered under his left armpit and made it almost to Reagan's heart. A well placed shot will do the job. Perhaps slowly, so take that into consideration.
Don't forget; Ronald Reagan was damn near killed by a .22lr. He was a big, muscular dude back in the day and Hinckley's bullet entered under his left armpit and made it almost to Reagan's heart. A well placed shot will do the job. Perhaps slowly, so take that into consideration.