I would vote for the Ruger Single Six too, slow loading and slow shooting, but dangit, it puts the bullets where they need to go(with a little help from me anyways). But I can't help any more than that b/c I don't recall shooting any other .22 pistols except the Mosquito and I just didn't feel right shooting a Sig Sauer .22...
I have a ruger single six and a sig .22.....you can't beat a ruger!